Search. Learn. Save

Platform for Pharmaceutical Products for Healthcare Professionals
Search By
☰ Generic Formulas

Generic Formulas X

Ceftazidime

Ceftazidime

Ceftazidime: A Comprehensive Review of its Uses, Benefits, and Side Effects

Ceftazidime is a third-generation cephalosporin antibiotic that has been widely used to treat various bacterial infections.

What is Ceftazidime?

Ceftazidime is an intravenous antibiotic that belongs to the cephalosporin class. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria. Ceftazidime works by inhibiting the synthesis of the bacterial cell wall, ultimately leading to the death of the bacteria.

Uses of Ceftazidime

Ceftazidime is commonly used to treat various bacterial infections, including:

  • Pneumonia: Ceftazidime is effective against pneumonia caused by bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and Klebsiella pneumoniae.

  • Urinary Tract Infections (UTIs): Ceftazidime is used to treat UTIs caused by bacteria such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

  • Septicemia: Ceftazidime is effective against septicemia caused by bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and Klebsiella pneumoniae.

  • Meningitis: Ceftazidime is used to treat meningitis caused by bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis.

Benefits of Ceftazidime

Ceftazidime has several benefits, including:

  • Broad-spectrum activity: Ceftazidime is effective against a wide range of bacteria, making it a versatile antibiotic.

  • Intravenous administration: Ceftazidime is available in intravenous form, making it a convenient option for patients who require hospitalization.

  • Convenient dosing: Ceftazidime is typically administered every 8-12 hours, making it a convenient option for patients.

  • Well-tolerated: Ceftazidime is generally well-tolerated, with few side effects reported.

Side Effects of Ceftazidime

While ceftazidime is generally well-tolerated, it can cause side effects, including:

  • Gastrointestinal symptoms: Nausea, vomiting, diarrhea, and abdominal pain are common side effects of ceftazidime.

  • Allergic reactions: Some patients may experience allergic reactions, including rash, itching, and hives.

  • Headache and fatigue: Ceftazidime can cause headache and fatigue in some patients.

  • Clostridioides difficile-associated diarrhea: Ceftazidime can increase the risk of Clostridioides difficile-associated diarrhea.

Precautions and Contraindications

Ceftazidime should be used with caution in patients with:

  • Penicillin allergy: Patients allergic to penicillin may also be allergic to ceftazidime.

  • Kidney disease: Ceftazidime may accumulate in patients with kidney disease, increasing the risk of side effects.

  • Liver disease: Ceftazidime may not be suitable for patients with liver disease, as it can affect liver function.

Interactions with Other Medications

Ceftazidime may interact with other medications, including:

  • Antacids: Antacids may reduce the absorption of ceftazidime.

  • Probenecid: Probenecid may increase the levels of ceftazidime in the body.

  • Warfarin: Ceftazidime may increase the risk of bleeding when taken with warfarin.

Comparison with Other Antibiotics

Ceftazidime is often compared to other antibiotics, including:

  • Ceftriaxone: Ceftazidime has a broader spectrum of activity than ceftriaxone.

  • Cefepime: Ceftazidime has a longer half-life than cefepime, making it a more convenient option.

  • Meropenem: Ceftazidime is effective against a wider range of bacteria than meropenem.

Conclusion

Ceftazidime is a versatile and effective antibiotic that is widely used to treat various bacterial infections. While it is generally well-tolerated, it can cause side effects and interact with other medications. Patients should consult their doctor before taking ceftazidime, especially if they have a history of allergies or kidney or liver disease.

Avaiable Medicines